According to the review from "luridsocerer" it will not work:
No, it REALLY won't work with US NES-101
I thought I knew some tricks to bypass the incompatibility. Disabling the NES10 lockout chip did not help. The adapter did not fit fully onto the contacts, so I thought a Game Genie would help. It made contact, but my Famicom cart was still not read.
For an NTSC original NES console, you need a different adapter. Please heed the description!
My friend has a knockoff console, so it looks like he's getting an early Christmas present.
Though when it comes to price, you can get the same adaptor off aliexpress for cheaper.