Famicom Box carts work just like any other cart, they're simply games with a special region-lock in NES form factor. The Pin-out is the same as the NES.
They played fine on my unmodded Sharp Titler Famicom with an NES adaptor (Guess the Titler has no lock), played by just plugging into a top-loader US NES with no modification or adaptor needed (Top-Loader has no lockout chip), and will play on an old original toaster NES if you clip pin #4 on the lockout chip inside the console. As a matter of fact, I was playing a Black Hotel Box cart on my boring old Toaster NES that has had the lockout chip disabled just this very morning.
All the consoles that aren't locked that I've owned listed above do play these games.
Here's some quick candid photographic evidence. There's nothing super special about these carts that make them unplayable.
Yes, the carts are locked. The lock is easily bypassed in the same generic ways that you bypass any other Fami/NES lock.